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(IN-su-lin)A 42-year-old HIV-positive woman's saquinavir in her highly active antiretroviral therapy was replaced with this drug to increase compliance. Two weeks after initiation, the patient reported severe and constant burning in her tongue, gums, and oral mucosa and was diagnosed with burning mouth syndrome (BMS). Efavirenz (the active ingredient contained in Sustiva) was discontinued and the BMS resolved within a week.[Ref]

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For full details, see the summary of product characteristics (also part of the EPAR).6. Clarke S, Harrington P, Barry M, Mulcahy F "The tolerability of efavirenz after nevirapine-related adverse events." Clin Infect Dis 31 (2000): 806-7

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the third study compared adding Sustiva or placebo (a dummy treatment) to a combination of antiviral medicines that included indinavir and two other antiviral medicines, in patients who had already been receiving treatment for HIV infection.

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If you have undiagnosed and/or unexplained abnormal vaginal bleeding, do not take Generic Ovral. worsening heartburn; or

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